Proiect CNCS-UEFISCDI, PN-III-P2-2.1-PED-2019-3664 - ”Personalized intelligent matrices for tissue regeneration and meta-inflammation control” (PRIM_TISS), Nr. 348PED/03.08.2020

Coordonator (CO) - UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU„

Prof. Dr. Ilea Aranka
Research member,
Project leader
Assoc. Prof. Dr. Boșca Adina Bianca
Research member
Assoc. Prof. Dr. Soanca Andrada
Research member
Assoc. Prof. Dr. Mesaroș Anca Stefania
Research member
Assoc. Prof. Dr. Dinte Elena
Research member
Asist. Prof. Dr. Muntean Dana Maria
Research member
Asist. Prof. Dr. Lazar Adela
Postdoctoral member
Asist. Prof. Dr. Pop Andreea Simona
Postdoctoral member
Asist. Prof. Drd. Babțan Anida Maria
PhD student
Asist. Prof. Drd. Uriciuc Willi Andrei
PhD student

Partener (P1) - UNIVERSITATEA BABES BOLYAI

Assoc. Prof. Dr. Ing. Reka Barabas
Research member,
Scientific responsible P1
Lecturer Dr. Ing. Liliana Bizo
Research member
Judith Bartha-Vári
Postdoctoral researcher

Partener (P2) - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD FILIALA INSTITUTUL DE CERCETARI PENTRU INSTRUMENTATIE ANALITICA CLUJ NAPOCA

CS I Dr. Oana Cadar
Senior researcher
Scientific responsible P2
CS I Dr. Erika Levei
Senior researcher
CS III Dr. Alexandra Hoaghia
Postdoctoral researcher
CS III Dr. Iulia Torok
Postdoctoral researcher
CS III Dr. Daniela Scurtu
Postdoctoral researcher
Bogdan Angyus
PhD student

Objectives

  • The aim of PRIM-TISS is to validate at laboratory scale TRL4:
  • a new product (a matrix system based on polylactic acid (PLA) and nano-hydroxyapatite (nano-HAP) with embedded silver (Ag) and Doxycycline(Doxy)
  • a new method of treatment (personalized multimodal and sequential treatment targeted against periodontal pathogens) of periodontal disease.

WP1. Study design of PRIM-TISS and preliminary results (TRL3) (8 months)

  • WP1.1. Review of existing technical documentation: therapy and intelligent matrices (nanofibers) (A2.1).
  • WP1.2. Development of nanofibers (nanofiber + active substance) to TRL3 and their physico-chemical characterization (A2.2+A2.3+A2.4)
  • WP1.3. Preparation and in vitro characterization of Doxy-based mucoadhesive topical drug delivery system able to be used in the in vivo studies for the topical noninvasive treatment of periodontitis (A2.4).
  • WP1.4. Material and method for obtaining the mucoadhesive system TRL4 - technology validated in lab (A2.4)
  • WP1.5. Results dissemination (D1+D2)

WP2. Therapy integration studies - personalized intelligent matrices and demonstration of the concept's functionality (TRL3) (12 months)

  • WP2.1. Nanofibers experimentation: adsorption/ desorption and kinetics studies (A2.4).
  • WP2.2. Establishment of sequential release of active subtances from nanofibers (A2.4)
  • WP2.3. Development of the antibiotics embedding in the mucoadhesive system with slow release (A2.3.).
  • WP2.4. Elaboration of a clinical model of implantation of the intelligent matrix in the patients (A2.2)
  • WP2.5. Realization of the personalized intelligent matrix by adsorption and incorporation of the antibiotic necessary and useful to each patient, according to the initial antibiogram (A2.4).
  • WP2.6. Application of personalized sequential treatment (A2.4) Data analysis and interpretation.
  • WP2.7. Clinical follow-up of patients for 3 months.
  • WP2.8. Demonstrating the utility and functionality of PRIM-TISS EM (A2.6)
  • WP2.9. Dissemination (D1+D2).

WP3. Validation at lab scale of PRIM-TISS (materials + method of treatment) - TRL4 (4 months)

  • WP3.1. Validation at lab scale
  • WP3.2. Valorization possibility of PRIM-TISS materials + method of treatment (A2.1)
  • WP3.3. Dissemination (D1+D2)

WP4. Management activities (24 months)

 

Livrabile 2020

  • Masă rotundă: ”Materiale inovative în regenerarea tisulară – Quo vadis?”, Zilele UMF ”Iuliu Hațieganu” Cluj-Napoca, 10 Decembrie, 2020, orele 12-14, Online_Platforma Microsoft Teams
  • Anida-Maria Băbțan, Daniela Timuș, Olga Sorițău, Bianca Adina Boșca, Reka Barabas, Anca Ionel, Nausica Bianca Petrescu, Claudia Nicoleta Feurdean, Ioana Roxana Bordea, George Saraci, Ştefan Cristian Vesa, Aranka Ilea. Tissue Integration and Biological Cellular Response of SLM-Manufactured Titanium Scaffolds. Metals 2020;10(9),1192; https://doi.org/10.3390/met10091192 - 05 Sep 2020, ISI FI= 2.117 – Q1
  • Nausica B. Petrescu, Ancuta Jurj, Olga Soritau, Ondine P. Lucaciu, Noemi Dirzu, Lajos Raduly, Ioana Berindan-Neagoe, Mihai Cenariu, Bianca A. Bosca, Radu S. Campian, Aranka Ilea. Cannabidiol and Vitamin D3 Impact on Osteogenic Differentiation of Human Dental Mesenchymal Stem Cells. Medicina 2020;56(11),607; https://doi.org/10.3390/medicina56110607, ISI FI= 1.205 – Q3
  • Capitol de carte: Băbțan Anida-Maria, Boșca Adina Bianca, Miclăuș Viorel, Ruxanda Flavia, Rațiu Cristian Adrian, Ionel Anca, Ilea Aranka. Hiperplazia gingivală indusă medicamentos, în cartea ”Cazuri clinice. Prezentări de medicală și chirurgie”. Coordonatori: Ștefan Cristian Vesa și Antonia Eugenia Macarie. Volumul XII. Editura Bioflux, Cluj-Napoca, 2020; pg. 31- 48. ISBN 978-606-8887-32-6; ISBN 978-606-8887-82-1